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Does memantine cause confusion? It has been shown to have neuroprotective effects by inhibiting the excitotoxic effect of NMDA glutamate receptors. Memantine has a tolerability profile similar to placebo. However, the worsening of psychotic symptoms in patients with Lewy body dementia (LBD) treated with memantine has been recently reported.
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Why is memantine prescribed? Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain.
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