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How long does it take for HRT to start working? It usually takes a few weeks before you will feel the initial benefits of HRT and up to three months to feel the full effects. It may also take your body time to get used to HRT. When treatment begins you may experience side effects such as breast tenderness, nausea and leg cramps.
Does hormone replacement therapy increase cholesterol? Estrogen use is associated with lower total and LDL cholesterol and triglyceride levels and a higher HDL cholesterol level. Estrogen plus progestin opposes some of these effects, but overall, HRT induces favorable changes. However, estrogen also has a prothrombotic effect.
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